A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

Long Jiao; Fengling Song; Jingnan Cui; Xiaojun Peng

doi:10.1039/C8CC04582H

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A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy†

Long Jiao,^a Fengling Song,

*^a Jingnan Cui^a and Xiaojun Peng

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* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, High-tech District, Dalian, China
E-mail: songfl@dlut.edu.cn

Abstract

A water-soluble near-infrared aminocyanine dye has been developed with a long triplet-state lifetime (τ = 9.16 μs in deaerated ethanol). Thereby, extremely high singlet oxygen quantum yield (Φ_Δ = 0.20) and low dark cytotoxicity (IC₅₀ = 715.4 μM) were achieved. The potential of the dye as a PDT photosensitizer was demonstrated.

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Article information

DOI: https://doi.org/10.1039/C8CC04582H
Article type: Communication
Submitted: 08 Jun 2018
Accepted: 24 Jul 2018
First published: 25 Jul 2018

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Chem. Commun., 2018,54, 9198-9201

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A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

L. Jiao, F. Song, J. Cui and X. Peng, Chem. Commun., 2018, 54, 9198 DOI: 10.1039/C8CC04582H

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Chemical Communications

A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy†

Abstract

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A near-infrared heptamethine aminocyanine dye with a long-lived excited triplet state for photodynamic therapy

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