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A new shape memory hydrogel, which can be programmed with quadruple geometries when stimuli are applied sequentially, is presented. With a new redox-responsive stimulus coupled with two other common regulation mechanisms, this hydrogel shows multiple shape memory behaviours, which is promising for various applications, especially drug delivery.

Graphical abstract: Ca2+, redox, and thermoresponsive supramolecular hydrogel with programmed quadruple shape memory effect

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