Hirokazu Tsukamoto, Kazuya Ito and Takayuki Doi
Chem. Commun., 2018,54, 5102-5105
DOI:
10.1039/C8CC02589D,
Communication
Multi-substituted dihydrofurans were obtained from a palladium-catalysed coupling reaction between 2,3-alkadienols and ketones bearing an electron-withdrawing group at the α-position. Methanol as a solvent was essential for the initial dehydrative substitution to suppress the competitive hydroalkylation of the diene moiety. The substitution would be followed by intramolecular hydroalkoxylation under the same catalysis.
