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Issue 40, 2018
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Highly hindered 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazoles: a new tool for the aqueous 19F- and 18F-fluorination of biomolecule-based structures

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Abstract

A new class of silicon-based fluoride acceptors with a C-linked heterocycle as the leaving group was synthesized in one step from commercial chemicals, and linked to biomolecules. The resulting conjugates were efficiently 19F-fluorinated in aqueous mixtures, and switching to 18F-labelling provided nucleoside- and peptide-based bioconjugates with excellent molar activities suitable for biological applications.

Graphical abstract: Highly hindered 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazoles: a new tool for the aqueous 19F- and 18F-fluorination of biomolecule-based structures

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Publication details

The article was received on 05 Mar 2018, accepted on 22 Apr 2018 and first published on 01 May 2018


Article type: Communication
DOI: 10.1039/C8CC01782D
Citation: Chem. Commun., 2018,54, 5098-5101
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    Highly hindered 2-(aryl-di-tert-butylsilyl)-N-methyl-imidazoles: a new tool for the aqueous 19F- and 18F-fluorination of biomolecule-based structures

    M. Tisseraud, J. Schulz, D. Vimont, M. Berlande, P. Fernandez, P. Hermange and E. Fouquet, Chem. Commun., 2018, 54, 5098
    DOI: 10.1039/C8CC01782D

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