Yang Li, Tianyi Kang, Yujiao Wu, Yuwen Chen, Jiao Zhu and Maling Gou
Chem. Commun., 2018,54, 1996-1999
DOI:
10.1039/C8CC00639C,
Communication
We report that carbonate esters could turn hydrophobic camptothecin (CPT)-unsaturated fatty acid prodrugs into nanoaggregates in aqueous solution. The active CPT could be rapidly released once triggered by a reductive stimulus when a carbonate ester was combined with a disulfide bond, resulting in a potent in vivo antitumor activity.
