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Issue 1, 2018
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Recent advances in the use of microfluidic technologies for single cell analysis

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Abstract

The inherent heterogeneity in cell populations has become of great interest and importance as analytical techniques have improved over the past decades. With the advent of personalized medicine, understanding the impact of this heterogeneity has become an important challenge for the research community. Many different microfluidic approaches with varying levels of throughput and resolution exist to study single cell activity. In this review, we take a broad view of the recent microfluidic developments in single cell analysis based on microwell, microchamber, and droplet platforms. We cover physical, chemical, and molecular biology approaches for cellular and molecular analysis including newly emerging genome-wide analysis.

Graphical abstract: Recent advances in the use of microfluidic technologies for single cell analysis

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Article information


Submitted
13 Aug 2017
Accepted
25 Oct 2017
First published
26 Oct 2017

Analyst, 2018,143, 60-80
Article type
Critical Review

Recent advances in the use of microfluidic technologies for single cell analysis

T. W. Murphy, Q. Zhang, L. B. Naler, S. Ma and C. Lu, Analyst, 2018, 143, 60 DOI: 10.1039/C7AN01346A

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