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Issue 10, 2018
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Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash

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Abstract

The activity of edible Nepeta nuda L. (Lamiaceae) tincture and Listerine towards a selected group of oral pathogenic microorganisms (4 bacterial and 9 fungal strains) has been explored. Their potentials to inhibit the formation of biofilm and to diminish established biofilm have been compared. The amount of N. nuda tincture and swishing time necessary for reaching better or equivalent antimicrobial effect than that of Listerine have been predicted. Phenolic compounds in N. nuda tincture are determined by LC-DAD/ESI-MSn. Both Listerine and N. nuda tincture possess good antimicrobial potentials (MIC in the range of 0.8–15 μL per well) including inhibition of biofilms. Rosmarinic acid and verminoside are the most dominant phenolic compounds present in the N. nuda tincture. Based on in vitro results, we infer that it is more desirable to swish 20 mL of mouthwashes (Listerine and N. nuda tincture, 100 mg mL−1) for 30 s when dealing with selected microorganisms in general and for 60 s (N. nuda tincture) when dealing with bacterial biofilms.

Graphical abstract: Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash

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Article information


Submitted
21 Jul 2018
Accepted
17 Sep 2018
First published
18 Sep 2018

Food Funct., 2018,9, 5417-5425
Article type
Paper

Characterization of phenolic compounds in tincture of edible Nepeta nuda: development of antimicrobial mouthwash

M. Smiljković, M. I. Dias, D. Stojković, L. Barros, D. Bukvički, I. C. F. R. Ferreira and M. Soković, Food Funct., 2018, 9, 5417
DOI: 10.1039/C8FO01466C

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