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Issue 90, 2018
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Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

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Abstract

We describe here the first enantioselective oxidative heterocoupling of enolates. Our strategy relies on the memory of chirality concept and allows the stereocontrolled formation of quaternary centres on α-amino acid derivatives with an enantiomeric excess of up to 94%.

Graphical abstract: Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

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Article information


Submitted
23 Aug 2018
Accepted
18 Oct 2018
First published
18 Oct 2018

Chem. Commun., 2018,54, 12742-12745
Article type
Communication

Oxidative coupling of enolates using memory of chirality: an original enantioselective synthesis of quaternary α-amino acid derivatives

A. Mambrini, D. Gori, R. Guillot, C. Kouklovsky and V. Alezra, Chem. Commun., 2018, 54, 12742
DOI: 10.1039/C8CC06864J

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