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Issue 90, 2018
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From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom

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Abstract

The present study aims to develop chlorotoxin (CTX), from Giant Yellow Israeli scorpion venom, as a new BBB-shuttle. Minimised versions of CTX were prepared to reduce its complexity while enhancing its BBB-shuttle capacity and preserving its protease-resistance. MiniCTX3, a monocyclic lactam-bridge peptidomimetic, was capable of transporting nanoparticles across endothelial cell monolayers. Our results reveal animal venoms as an outstanding source of new families of BBB-shuttles.

Graphical abstract: From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom

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Article information


Submitted
18 Aug 2018
Accepted
16 Oct 2018
First published
25 Oct 2018

Chem. Commun., 2018,54, 12738-12741
Article type
Communication

From venoms to BBB-shuttles. MiniCTX3: a molecular vector derived from scorpion venom

C. Díaz-Perlas, M. Varese, S. Guardiola, J. García, M. Sánchez-Navarro, E. Giralt and M. Teixidó, Chem. Commun., 2018, 54, 12738
DOI: 10.1039/C8CC06725B

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