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Issue 51, 2017
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Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

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Abstract

The review discusses the progress in the design and synthesis of bioactive agents incorporated into vascular grafts obtained by the electrospinning process. Electrospun fibers can be applied as an artificial extracellular matrix for tissue engineering and drug delivery, improving tissue regeneration and therapeutic outcomes. A large number of active substances are loaded into the fibers, such as growth factors, heparin, NO donors, statins, antibiotics or anti-inflammatory agents. There are various methods for bioactive substance incorporation including direct blending, emulsion, and coaxial electrospinning as well as covalent and non-covalent binding of the bioactive molecules to the fiber surface. The release mechanism of the drug depends on the synthesis route, active substance properties, and polymer matrix nature. The electrospun materials represent a very promising building block for the fabrication of effective vascular prosthesis in the near future.

Graphical abstract: Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

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Publication details

The article was received on 27 Apr 2017, accepted on 08 Jun 2017 and first published on 23 Jun 2017


Article type: Review Article
DOI: 10.1039/C7RA04735E
Citation: RSC Adv., 2017,7, 32164-32184
  • Open access: Creative Commons BY license
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    Progress and perspectives in bioactive agent delivery via electrospun vascular grafts

    M. Rychter, A. Baranowska-Korczyc and J. Lulek, RSC Adv., 2017, 7, 32164
    DOI: 10.1039/C7RA04735E

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