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Issue 14, 2017, Issue in Progress
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First step towards a model system of the drug delivery network based on amide-POSS nanocarriers

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Abstract

Among the varied and diverse family of drug delivery systems (DDSs), such as polymer–drug conjugates, polymeric micelles, dendrimers and molecular containers, polyhedral oligomeric silsesquioxanes (POSS) occupy a special position within the group of biocompatible drug carriers. The extraordinary recommendation of POSS for such systems derives from their three-dimensional structure, nanoscale size, low toxicity, and efficient cellular uptake. These conjugates can be strictly designed compared for instance to micelles, dendrimeric-drug or polymer/inorganic hybrid composites, in which the amount of therapeutics attached to the carrier is rather random, and there is a high probability that some of the drug molecules can be completely trapped inside the ramified structures. The combination of fully functionalized amide-POSS and pharmaceuticals might create a so-called sophisticated DDS. In such a system, the adsorbed drug molecules can be released under physiological conditions and then the POSS-based carrier will be hydrolyzed (at pH = 7.40) to a non-toxic carboxylic acid salt and a water soluble polyhedral oligomeric silsesquioxane containing an aminopropyl group that can be safely removed from the organism.

Graphical abstract: First step towards a model system of the drug delivery network based on amide-POSS nanocarriers

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Supplementary files

Article information


Submitted
04 Nov 2016
Accepted
19 Jan 2017
First published
26 Jan 2017

This article is Open Access

RSC Adv., 2017,7, 8394-8401
Article type
Paper

First step towards a model system of the drug delivery network based on amide-POSS nanocarriers

Ł. John, M. Malik, M. Janeta and S. Szafert, RSC Adv., 2017, 7, 8394
DOI: 10.1039/C6RA26330E

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    [Original citation] - Published by The Royal Society of Chemistry.

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