Issue 48, 2017

A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

Abstract

A three component reaction with two different ketones and aromatic amines was firstly investigated. The difference in reactivity between ordinary ketones and ketone esters allowed for the production of 1,2-DHQs efficiently. The possible Skraup reaction with 2 equiv. of the same ketones was prohibited due to the fast formation of imines.

Graphical abstract: A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

Supplementary files

Article information

Article type
Communication
Submitted
16 Oct 2017
Accepted
20 Nov 2017
First published
20 Nov 2017

Org. Biomol. Chem., 2017,15, 10167-10171

A one pot three-component reaction for the preparation of dihydroquinolines with two different ketones and aromatic amines

G. Yang, G. Li, J. Huang, Z. Tang and J. Zhao, Org. Biomol. Chem., 2017, 15, 10167 DOI: 10.1039/C7OB02554H

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