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Issue 35, 2017
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An enzymatic strategy to asymmetrically branched N-glycans

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Abstract

An enzymatic strategy was developed to generate asymmetrically branched N-glycans from natural sources by using a panel of glycosidases and glycosyltransferases. Briefly, LacZ β-galactosidase was employed to selectively trim symmetrically branched N-glycans isolated from bovine fetuin. The yielding structures were then converted to asymmetrically branched core structures by robust glycosyltransferase for further extension.

Graphical abstract: An enzymatic strategy to asymmetrically branched N-glycans

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Article information


Submitted
18 Jul 2017
Accepted
15 Aug 2017
First published
15 Aug 2017

Org. Biomol. Chem., 2017,15, 7258-7262
Article type
Communication

An enzymatic strategy to asymmetrically branched N-glycans

A. D. Calderon, J. Zhou, W. Guan, Z. Wu, Y. Guo, J. Bai, Q. Li, P. G. Wang, J. Fang and L. Li, Org. Biomol. Chem., 2017, 15, 7258
DOI: 10.1039/C7OB01765K

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