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Issue 27, 2017
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Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

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Abstract

Here we show the first example of an immunoreceptor tyrosine-based inhibitory motif (ITIM), LYYYYL, as well as its enantiomeric or retro-inverso peptide, to self-assemble in water via enzyme-instructed self-assembly. Upon enzymatic dephosphorylation, the phosphohexapeptides become hexapeptides, which self-assemble in water to result in supramolecular hydrogels. This work illustrates a new approach to design bioinspired soft materials from a less explored, but important pool of immunomodulatory peptides.

Graphical abstract: Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

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Article information


Submitted
03 May 2017
Accepted
22 Jun 2017
First published
26 Jun 2017

Org. Biomol. Chem., 2017,15, 5689-5692
Article type
Communication

Enzymatic self-assembly of an immunoreceptor tyrosine-based inhibitory motif (ITIM)

N. Yamagata, X. Chen, J. Zhou, J. Li, X. Du and B. Xu, Org. Biomol. Chem., 2017, 15, 5689
DOI: 10.1039/C7OB01074E

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