Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 18, 2017
Previous Article Next Article

Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4

Author affiliations

Abstract

Cultivation of locust associated rare actinobacteria, Amycolatopsis sp. HCa4, has provided five unusual macrolactams rifamorpholines A–E. Their structures were determined by interpretation of spectroscopic and crystallographic data. Rifamorpholines A–E possess an unprecedented 5/6/6/6 ring chromophore, representing a new subclass of rifamycin antibiotics. The biosynthetic pathway for compounds 1–5 involves a key 1,6-cyclization for the formation of the morpholine ring. Compounds 2 and 4 showed potent activities against methicillin-resistant Staphylococcus aureus (MRSA) with MICs of 4.0 and 8.0 μM, respectively.

Graphical abstract: Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4

Back to tab navigation

Supplementary files

Article information


Submitted
12 Mar 2017
Accepted
03 Apr 2017
First published
03 Apr 2017

Org. Biomol. Chem., 2017,15, 3909-3916
Article type
Paper

Rifamorpholines A–E, potential antibiotics from locust-associated actinobacteria Amycolatopsis sp. Hca4

Y. S. Xiao, B. Zhang, M. Zhang, Z. K. Guo, X. Z. Deng, J. Shi, W. Li, R. H. Jiao, R. X. Tan and H. M. Ge, Org. Biomol. Chem., 2017, 15, 3909
DOI: 10.1039/C7OB00614D

Social activity

Search articles by author

Spotlight

Advertisements