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Issue 16, 2017
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Amidation of unactivated ester derivatives mediated by trifluoroethanol

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Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides. The complete scope and limitations of the method are described, along with modified conditions for challenging substrates such as acyclic secondary amines and chiral esters with retention of chiral integrity.

Graphical abstract: Amidation of unactivated ester derivatives mediated by trifluoroethanol

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Article information


Submitted
09 Mar 2017
Accepted
04 Apr 2017
First published
04 Apr 2017

Org. Biomol. Chem., 2017,15, 3507-3518
Article type
Paper

Amidation of unactivated ester derivatives mediated by trifluoroethanol

C. G. McPherson, N. Caldwell, C. Jamieson, I. Simpson and A. J. B. Watson, Org. Biomol. Chem., 2017, 15, 3507
DOI: 10.1039/C7OB00593H

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