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Issue 5, 2017
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A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

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Abstract

A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)–C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A plausible biosynthetic pathway for 1 is also discussed.

Graphical abstract: A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

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Supplementary files

Article information


Submitted
05 Dec 2016
Accepted
04 Jan 2017
First published
04 Jan 2017

Org. Biomol. Chem., 2017,15, 1110-1114
Article type
Communication

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

C. Sun, A. G. Kutateladze, F. Zhao, L. Chen and F. Qiu, Org. Biomol. Chem., 2017, 15, 1110
DOI: 10.1039/C6OB02656G

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