Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

Gaia Fumagalli; Michael S. Christodoulou; Benedetta Riva; Inigo Revuelta; Cristina Marucci; Veronica Collico; Davide Prosperi; Sergio Riva; Dario Perdicchia; Ivan Bassanini; Aida García-Argáez; Lisa Dalla Via; Daniele Passarella

doi:10.1039/C6OB02591A

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks†

Gaia Fumagalli,‡^a Michael S. Christodoulou,‡^a Benedetta Riva,‡^b Inigo Revuelta,

^a Cristina Marucci,^a Veronica Collico,^b Davide Prosperi,^b Sergio Riva,^c Dario Perdicchia,^a Ivan Bassanini,^ac Aida García-Argáez,^de Lisa Dalla Via^d and Daniele Passarella

*^a

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* Corresponding authors

^a Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy
E-mail: daniele.passarella@unimi.it

^b Dipartimento di Biotecnologie e Bioscienze - Università degli Studi di Milano Bicocca, Piazza della scienza 2, 20126 Milano, Italy

^c Istituto di Chimica del Riconoscimento Molecolare - C.N.R., Via Mario Bianco 9, 20131 Milano, Italy

^d Dipartimento di Scienze del Farmaco - Università degli Studi di Padova, Via F. Marzolo 5, 35131 Padova, Italy

^e Fondazione per la Biologia e la Medicina della Rigenerazione T.E.S.-Tissue Engineering and Signalling Onlus, Via F. Marzolo, 13, 35131 Padova, Italy

Abstract

The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.

Organic & Biomolecular Chemistry

Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks†

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Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks

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