Issue 5, 2017
From the journal:

Organic & Biomolecular Chemistry

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata†

Cheng-Peng Sun,ab   Andrei G. Kutateladze,c   Feng Zhao,d   Li-Xia Chen*b  and  Feng Qiu ORCID logo *ab  

* Corresponding authors

a Tianjin State Key Laboratory of Modern Chinese Medicine and School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 312 Anshanxi Road, Nankai District, Tianjin 300193, China
E-mail: fengqiu20070118@163.com

b Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
E-mail: syzyclx@163.com

c Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208, USA

d School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China

Abstract

A novel withanolide, aromaphysalin A (1), possessing an exceptional C(11)–C(15) bond and an unprecedented 4,9-cyclized aromatic ring (ring A), is isolated from stems and leaves of Physalis angulata L. Its structure was determined by a combination of HRESIMS, 2D NMR spectra, and theoretical calculations. Compound 1 exhibited inhibitory activity on NO production with an IC50 value of 51.64 μM. A plausible biosynthetic pathway for 1 is also discussed.

Graphical abstract: A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C6OB02656G
Article type
Communication
Submitted
05 Dec 2016
Accepted
04 Jan 2017
First published
04 Jan 2017

Org. Biomol. Chem., 2017,15, 1110-1114

Permissions

Request permissions

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

C. Sun, A. G. Kutateladze, F. Zhao, L. Chen and F. Qiu, Org. Biomol. Chem., 2017, 15, 1110 DOI: 10.1039/C6OB02656G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements