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Issue 6, 2017
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A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

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Abstract

The synthesis and properties of 2,7-diamino-1,4,8-triazanaphthalene (azaDANP) are described. AzaDANP is protonated only at a weakly acidic pH to bind to the cytosine bulge DNA duplex selectively. Upon binding of azaDANP to the cytosine bulge DNA, a new absorption band at 407 nm appears, and the absorption change of azaDANP on binding to the target is very sensitive to environmental pH with a bell-shaped pH–absorption profile.

Graphical abstract: A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

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Article information


Submitted
18 Oct 2016
Accepted
08 Nov 2016
First published
09 Nov 2016

Org. Biomol. Chem., 2017,15, 1313-1316
Article type
Communication

A 2,7-diamino-1,4,8-triazanaphthalene derivative selectively binds to cytosine bulge DNA only at a weakly acidic pH

H. Aikawa, A. Yano and K. Nakatani, Org. Biomol. Chem., 2017, 15, 1313
DOI: 10.1039/C6OB02273A

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