Issue 9, 2017
From the journal:

Molecular BioSystems

Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death†

T. Takatani-Nakase, ORCID logo *a   M. Katayama,bc   C. Matsui,a   K. Hanaoka,d   A. J. van der Vlies,e   K. Takahashi,a   I. Nakase ORCID logo *b  and  U. Hasegawa ORCID logo *e  

* Corresponding authors

a School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women's University, 11-68, Koshien Kyuban-cho, Nishinomiya, Hyogo 663-8179, Japan
E-mail: nakase@mukogawa-u.ac.jp

b Nanoscience and Nanotechnology Research Center, Research Organization for the 21st Century, Osaka Prefecture University, 1-2, Gakuen-cho, Naka-ku, Osaka 599-8570, Japan
E-mail: i-nakase@21c.osakafu-u.ac.jp

c Graduate School of Science, Osaka Prefecture University, 1-1, Gakuen-cho, Naka-ku, Osaka 599-8531, Japan

d Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

e The Department of Chemical Engineering, Kansas State University, 1005 Durland Hall, 1701A Platt Street, Manhattan, KS 66506, USA
E-mail: hasegawa@ksu.edu

Abstract

Hydrogen sulfide, an important gaseous signaling molecule in the human body, is known to protect cardiomyocytes from ischemia, a condition characterized by insufficient oxygen supply to the cells. Here we show that a nanosized H2S donor micelle releases H2S intracellularly and prevents cardiomyocyte apoptosis in an in vitro ischemia model.

Graphical abstract: Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death

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Article information

DOI
https://doi.org/10.1039/C7MB00191F
Article type
Communication
Submitted
30 Mar 2017
Accepted
23 Jun 2017
First published
28 Jun 2017

Mol. BioSyst., 2017,13, 1705-1708

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Hydrogen sulfide donor micelles protect cardiomyocytes from ischemic cell death

T. Takatani-Nakase, M. Katayama, C. Matsui, K. Hanaoka, A. J. van der Vlies, K. Takahashi, I. Nakase and U. Hasegawa, Mol. BioSyst., 2017, 13, 1705 DOI: 10.1039/C7MB00191F

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