Issue 91, 2017

cis-Specific cyanofluorination of vinyl azides enabled by electron-donor–acceptor complexes: synthesis of α-azido-β-fluoronitriles

Abstract

Here we report a novel electron-donor–acceptor (EDA) complex-enabled three-component cyanofluorination of vinyl azides under metal-free conditions in a cis-specific manner. This reaction protocol is operationally simple without exclusion of either moisture or oxygen, allowing access to a wide range of highly-functionalized α-azido-β-fluoronitriles bearing quaternary carbons that are difficult to obtain by existing methods.

Graphical abstract: cis-Specific cyanofluorination of vinyl azides enabled by electron-donor–acceptor complexes: synthesis of α-azido-β-fluoronitriles

Supplementary files

Article information

Article type
Communication
Submitted
13 Sep 2017
Accepted
27 Oct 2017
First published
27 Oct 2017

Chem. Commun., 2017,53, 12321-12324

cis-Specific cyanofluorination of vinyl azides enabled by electron-donor–acceptor complexes: synthesis of α-azido-β-fluoronitriles

S. Wu, J. Liu and F. Liu, Chem. Commun., 2017, 53, 12321 DOI: 10.1039/C7CC07165E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements