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Issue 49, 2017
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A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

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Abstract

We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 μL. The breadth of compatible chemistries is successfully demonstrated and the desired products are characterized, isolated, and collected online by preparative HPLC/MS/ELSD.

Graphical abstract: A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

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Article information


Submitted
08 May 2017
Accepted
25 May 2017
First published
25 May 2017

Chem. Commun., 2017,53, 6649-6652
Article type
Communication

A segmented flow platform for on-demand medicinal chemistry and compound synthesis in oscillating droplets

Y. Hwang, C. W. Coley, M. Abolhasani, A. L. Marzinzik, G. Koch, C. Spanka, H. Lehmann and K. F. Jensen, Chem. Commun., 2017, 53, 6649
DOI: 10.1039/C7CC03584E

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