We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5′-CACGTG-3′ through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.
Y. Ruiz García, Y. V. Pabon-Martinez, C. I. E. Smith and A. Madder, Chem. Commun., 2017, 53, 6653 DOI: 10.1039/C7CC01705G
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