The copper-catalyzed selective mono-N-alkylation of primary amides with bis(trialkylsilyl) peroxides as alkylating agents was reported. The results of a mechanistic study suggest that this reaction should proceed via a free radical process that includes the generation of alkyl radicals from bis(trialkylsilyl) peroxides.
R. Sakamoto, S. Sakurai and K. Maruoka, Chem. Commun., 2017, 53, 6484 DOI: 10.1039/C7CC02910A
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