Tailor-made synthesis of fully alkylated/arylated nicotinates by FeCl3-mediated condensation of enamino esters with enones

Abstract

A new method for synthesizing polyalkylated/arylated nicotinates is established using a condensation of enamino esters with enones in the presence of FeCl₃. This method facilitates the introduction of alkyl or aryl groups at any position on demand, which has not been achieved by other procedures.