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Issue 10, 2017
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MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly

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Abstract

Controlling the self-assembly of multicomponent systems provides a key to designing new materials and understanding the molecular complexity of biology. Here, we demonstrate the first use of MALDI-imaging to characterize a multicomponent self-assembling peptide fiber. Observations of mixed peptide systems over time demonstrate how simple sequence variation can change the balance between kinetic and thermodynamic products.

Graphical abstract: MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly

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Article information


Submitted
21 Dec 2016
Accepted
12 Jan 2017
First published
13 Jan 2017

Chem. Commun., 2017,53, 1715-1718
Article type
Communication

MALDI-imaging enables direct observation of kinetic and thermodynamic products of mixed peptide fiber assembly

K. Medini, B. West, D. E. Williams, M. A. Brimble and J. A. Gerrard, Chem. Commun., 2017, 53, 1715
DOI: 10.1039/C6CC10146A

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