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Issue 10, 2017
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A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

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Abstract

A bioreductant-resistant ‘turn-on’ chemodosimetric fluorescent probe Mito-1 has been developed for the detection of mitochondrial HNO in live cells. Mito-1 enables the detection of HNO as low as ∼18 nM. It has the capability to detect both exogenous and endogenous mitochondrial HNO formations in cellular milieus by providing fluorescence images. Its two-photon imaging ability fosters its use as a noninvasive imaging tool for the detection of mitochondrial nitroxyl.

Graphical abstract: A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

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Publication details

The article was received on 14 Nov 2016, accepted on 10 Jan 2017 and first published on 10 Jan 2017


Article type: Communication
DOI: 10.1039/C6CC09082F
Chem. Commun., 2017,53, 1723-1726

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    A bioorthogonal ‘turn-on’ fluorescent probe for tracking mitochondrial nitroxyl formation

    K. Sunwoo, K. N. Bobba, J. Lim, T. Park, A. Podder, J. S. Heo, S. G. Lee, S. Bhuniya and J. S. Kim, Chem. Commun., 2017, 53, 1723
    DOI: 10.1039/C6CC09082F

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