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Issue 1, 2017
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Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

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Abstract

A metal-free and selective method to form [18F]aryl-CF2H through nucleophilic radiofluorination of benzyl (pseudo)halides and oxidative C–H activation of benzylic C–H bonds has been developed. The method is operationally simple and tolerates a variety of electron-neutral/deficient arenes and heteroarenes.

Graphical abstract: Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

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Supplementary files

Article information


Submitted
29 Sep 2016
Accepted
18 Nov 2016
First published
05 Dec 2016

Chem. Commun., 2017,53, 126-129
Article type
Communication

Metal-free 18F-labeling of aryl-CF2H via nucleophilic radiofluorination and oxidative C–H activation

G. Yuan, F. Wang, N. A. Stephenson, L. Wang, B. H. Rotstein, N. Vasdev, P. Tang and S. H. Liang, Chem. Commun., 2017, 53, 126
DOI: 10.1039/C6CC07913J

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