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Issue 44, 2017
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Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

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Abstract

We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.

Graphical abstract: Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

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Publication details

The article was received on 06 Apr 2017, accepted on 14 May 2017 and first published on 24 May 2017


Article type: Paper
DOI: 10.1039/C7RA03897F
RSC Adv., 2017,7, 27678-27681
  • Open access: Creative Commons BY-NC license
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    Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

    T. D. Michl, C. Giles, A. T. Cross, H. J. Griesser and B. R. Coad, RSC Adv., 2017, 7, 27678
    DOI: 10.1039/C7RA03897F

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