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Issue 44, 2017

Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

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Abstract

We report a facile, one-step, aqueous surface bioconjugation approach for producing an antifungal surface coating that prevents the formation of fungal biofilms. By direct reaction between surface epoxide groups and amine groups on caspofungin, it avoids the use of secondary chemicals. The coating withstands washing with detergent and reduces the growth of the fungal pathogens Candida albicans by log 6 and Candida glabrata by log 3. Importantly, we show that surface adsorption of albumin does not inhibit the activity of this antifungal coating.

Graphical abstract: Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

Supplementary files

Article information


Submitted
06 Apr 2017
Accepted
14 May 2017
First published
24 May 2017

This article is Open Access

RSC Adv., 2017,7, 27678-27681
Article type
Paper

Facile single-step bioconjugation of the antifungal agent caspofungin onto material surfaces via an epoxide plasma polymer interlayer

T. D. Michl, C. Giles, A. T. Cross, H. J. Griesser and B. R. Coad, RSC Adv., 2017, 7, 27678 DOI: 10.1039/C7RA03897F

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