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Issue 6, 2017
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Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84

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Abstract

Saturated hydroxy fatty acids make up a class of underexplored lipids with potentially interesting biological activities. We report a succinct and general synthetic route to saturated hydroxy fatty acids hydroxylated at position 6 or higher, and exemplify this with the synthesis of hydroxylauric acids. All regioisomers of hydroxylauric acids were tested on free fatty acid receptors FFA1, FFA4 and GPR84. The results show that the introduction of a hydroxy group and its position have a high impact on receptor activity.

Graphical abstract: Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84

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Supplementary files

Article information


Submitted
14 Mar 2017
Accepted
08 May 2017
First published
12 May 2017

Med. Chem. Commun., 2017,8, 1360-1365
Article type
Research Article

Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84

M. H. Kaspersen, L. Jenkins, J. Dunlop, G. Milligan and T. Ulven, Med. Chem. Commun., 2017, 8, 1360
DOI: 10.1039/C7MD00130D

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