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Issue 2, 2017
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Hepatoprotective standardized EtOH–water extract of the leaves of Ziziphus jujuba

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Abstract

The hepatoprotective activity of the EtOH–water extract of Ziziphus jujuba leaves was evaluated against CCl4-induced hepatic damage in mice. The EtOH–water extract significantly alleviated liver damage as indicated by the decreased levels of serum ALT and AST and the decreased MDA content, the increased levels of SOD, GSH and GSH-Px, and the reduced pathological tissue injury induced by CCl4. A quantitative analysis of fifteen major constituents (1–15) of the EtOH–water extract of the leaves of Z. jujuba was conducted by HPLC-DAD. Based on our research results, it can be concluded that the EtOH–water extract of the leaves of Z. jujuba is efficacious for prevention and treatment of CCl4-induced hepatic injury in mice. Flavonoids might be the active ingredients responsible for the biological and pharmacological activities towards hepatoprotection.

Graphical abstract: Hepatoprotective standardized EtOH–water extract of the leaves of Ziziphus jujuba

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Publication details

The article was received on 20 Nov 2016, accepted on 02 Jan 2017 and first published on 03 Jan 2017


Article type: Paper
DOI: 10.1039/C6FO01690A
Food Funct., 2017,8, 816-822

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    Hepatoprotective standardized EtOH–water extract of the leaves of Ziziphus jujuba

    L. Bai, X. Cui, N. Cheng, W. Cao, Y. Wu, S. Guo, L. Zhang, C. Ho and N. Bai, Food Funct., 2017, 8, 816
    DOI: 10.1039/C6FO01690A

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