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Issue 37, 2017
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Direct use of allylic alcohols and allylic amines in palladium-catalyzed allylic amination

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Abstract

Allylic alcohols and allylic amines were directly utilized in a Pd-catalyzed hydrogen-bond-activated allylic amination under mild reaction conditions in the absence of any additives. The cooperative action of a Pd-catalyst and a hydrogen-bonding solvent is most likely responsible for its high reactivity. The catalytic system is compatible with a variety of functional groups and can be used to prepare a wide range of linear allylic amines in good to excellent yields. Furthermore, this methodology can be easily applied to the one-step synthesis of two drugs, cinnarizine and naftifine, on a gram scale.

Graphical abstract: Direct use of allylic alcohols and allylic amines in palladium-catalyzed allylic amination

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Article information


Submitted
10 Feb 2017
Accepted
13 Apr 2017
First published
18 Apr 2017

Chem. Commun., 2017,53, 5151-5154
Article type
Communication

Direct use of allylic alcohols and allylic amines in palladium-catalyzed allylic amination

J. Jing, X. Huo, J. Shen, J. Fu, Q. Meng and W. Zhang, Chem. Commun., 2017, 53, 5151
DOI: 10.1039/C7CC01069A

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