Jump to main content
Jump to site search

Issue 2, 2017
Previous Article Next Article

[18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

Author affiliations

Abstract

[18F]-Fluoride ready for aromatic nucleophilic substitution was prepared according to a simple process including trapping of aqueous [18F]-fluoride on a cartridge pre-loaded with the phosphonium borane [(Ph2MeP)C6H4(BMes2)]+, then releasing by elution of TBACN in dry acetonitrile. Subsequent radiofluorination was successfully applied to a model reaction and to the radiosynthesis of [18F]-setoperone.

Graphical abstract: [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

Back to tab navigation

Supplementary files

Article information


Submitted
21 Jun 2016
Accepted
30 Nov 2016
First published
30 Nov 2016

Chem. Commun., 2017,53, 340-343
Article type
Communication

[18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane

C. Perrio, S. Schmitt, D. Pla, F. P. Gabbaï, K. Chansaenpak, B. Mestre-Voegtle and E. Gras, Chem. Commun., 2017, 53, 340
DOI: 10.1039/C6CC05168E

Social activity

Search articles by author

Spotlight

Advertisements