Issue 5, 2016

Surfactant-facilitated crystallisation of water-soluble foldamers


X-ray crystallography has played a major role in the advancement of foldamer research, however, obtaining well-formed single crystals of suitable quality for structure determination by X-ray diffraction methods is often rather challenging. Towards this end, we report here the ability of common surfactants to promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven highly resistant to crystallisation. Four high-resolution crystal structures are reported, suggesting certain surfactants could be potentially useful tools for the crystallisation of intractable water-soluble foldamers (or peptides).

Graphical abstract: Surfactant-facilitated crystallisation of water-soluble foldamers

Supplementary files

Article information

Article type
Edge Article
07 Jan 2016
10 Feb 2016
First published
10 Feb 2016
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2016,7, 3377-3383

Surfactant-facilitated crystallisation of water-soluble foldamers

G. W. Collie, K. Pulka-Ziach and G. Guichard, Chem. Sci., 2016, 7, 3377 DOI: 10.1039/C6SC00090H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity