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Issue 5, 2016
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Surfactant-facilitated crystallisation of water-soluble foldamers

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Abstract

X-ray crystallography has played a major role in the advancement of foldamer research, however, obtaining well-formed single crystals of suitable quality for structure determination by X-ray diffraction methods is often rather challenging. Towards this end, we report here the ability of common surfactants to promote the crystallisation of a series of water-soluble oligourea foldamers which had previously proven highly resistant to crystallisation. Four high-resolution crystal structures are reported, suggesting certain surfactants could be potentially useful tools for the crystallisation of intractable water-soluble foldamers (or peptides).

Graphical abstract: Surfactant-facilitated crystallisation of water-soluble foldamers

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Supplementary files

Article information


Submitted
07 Jan 2016
Accepted
10 Feb 2016
First published
10 Feb 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 3377-3383
Article type
Edge Article

Surfactant-facilitated crystallisation of water-soluble foldamers

G. W. Collie, K. Pulka-Ziach and G. Guichard, Chem. Sci., 2016, 7, 3377
DOI: 10.1039/C6SC00090H

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