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Issue 5, 2016
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Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

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Abstract

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(I)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.

Graphical abstract: Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

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Supplementary files

Article information


Submitted
28 Dec 2015
Accepted
09 Feb 2016
First published
09 Feb 2016

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 3313-3316
Article type
Edge Article

Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

K. Xu, Y. Wang, V. Khakyzadeh and B. Breit, Chem. Sci., 2016, 7, 3313
DOI: 10.1039/C5SC04984A

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