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Issue 5, 2016
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Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

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Abstract

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(I)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.

Graphical abstract: Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

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Publication details

The article was received on 28 Dec 2015, accepted on 09 Feb 2016 and first published on 09 Feb 2016


Article type: Edge Article
DOI: 10.1039/C5SC04984A
Citation: Chem. Sci., 2016,7, 3313-3316
  • Open access: Creative Commons BY license
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    Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

    K. Xu, Y. Wang, V. Khakyzadeh and B. Breit, Chem. Sci., 2016, 7, 3313
    DOI: 10.1039/C5SC04984A

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