Issue 112, 2016, Issue in Progress

Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

Abstract

Lung cancer is an aggressive deadly disease worldwide. In this research, PLGA microspheres were used as a co-delivery system of angiostatin and curcumin for the synergistic treatment of lung cancer. The formulations were characterized by morphology, mean diameter, surface potential, and in vitro release kinetics. Furthermore, dual-drug loaded microspheres exhibited a higher antiproliferative activity in endothelial cells but not in HepG2 cells. More importantly, compared with single-drug loaded Ms (AS–PLGA-Ms and Cur–PLGA-Ms), dual-drug loaded Ms (As–Cur–PLGA-Ms) exhibited higher antitumor activity, which was further confirmed by the systemic histological and immunohistochemical analyses.

Graphical abstract: Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

Article information

Article type
Paper
Submitted
22 Sep 2016
Accepted
11 Nov 2016
First published
16 Nov 2016

RSC Adv., 2016,6, 111440-111446

Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

Y. Cao, X. Yang, Y. Wu, J. Yi, Y. Wu, C. Yu, Y. Huang, Y. Bao, L. Sun and Y. Li, RSC Adv., 2016, 6, 111440 DOI: 10.1039/C6RA23627H

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