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Issue 112, 2016, Issue in Progress
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Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

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Abstract

Lung cancer is an aggressive deadly disease worldwide. In this research, PLGA microspheres were used as a co-delivery system of angiostatin and curcumin for the synergistic treatment of lung cancer. The formulations were characterized by morphology, mean diameter, surface potential, and in vitro release kinetics. Furthermore, dual-drug loaded microspheres exhibited a higher antiproliferative activity in endothelial cells but not in HepG2 cells. More importantly, compared with single-drug loaded Ms (AS–PLGA-Ms and Cur–PLGA-Ms), dual-drug loaded Ms (As–Cur–PLGA-Ms) exhibited higher antitumor activity, which was further confirmed by the systemic histological and immunohistochemical analyses.

Graphical abstract: Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

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Publication details

The article was received on 22 Sep 2016, accepted on 11 Nov 2016 and first published on 16 Nov 2016


Article type: Paper
DOI: 10.1039/C6RA23627H
RSC Adv., 2016,6, 111440-111446

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    Dual release of angiostatin and curcumin from biodegradable PLGA microspheres inhibit Lewis lung cancer in a mice model

    Y. Cao, X. Yang, Y. Wu, J. Yi, Y. Wu, C. Yu, Y. Huang, Y. Bao, L. Sun and Y. Li, RSC Adv., 2016, 6, 111440
    DOI: 10.1039/C6RA23627H

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