Enantioselective Diels–Alder reaction in the confined space of homochiral metal–organic frameworks

Abstract

A novel homochiral porous metal–organic framework (MOF) has been synthesized using (R)-2,2′-dihydroxy-1,1′-binaphthyl-4,4′-dibenzoic acid as the chiral ligand. This MOF acts as an effective heterogeneous catalyst for the enantioselective Diels–Alder reaction between isoprene and N-ethyl maleimide.