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Issue 99, 2016, Issue in Progress
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Copper-catalyzed N-(hetero)arylation of amino acids in water

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Abstract

An environmentally benign, mild, cost-effective and gram-scalable copper-catalyzed method for the N-(hetero)arylation of zwitterionic natural and unnatural amino acids using 2-isobutyrylcyclohexanone as a β-diketone ligand and aryl bromides as coupling partners in water for 50 min at 90 °C under microwave irradiation is reported. Electronically and sterically diverse aryl coupling partners were inserted efficiently, including challenging heteroaryl electrophilic partners in high yields without affecting the enantiopurity of the product.

Graphical abstract: Copper-catalyzed N-(hetero)arylation of amino acids in water

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Publication details

The article was received on 20 Sep 2016, accepted on 03 Oct 2016 and first published on 05 Oct 2016


Article type: Communication
DOI: 10.1039/C6RA23364C
RSC Adv., 2016,6, 96762-96767

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    Copper-catalyzed N-(hetero)arylation of amino acids in water

    K. K. Sharma, M. Mandloi, N. Rai and R. Jain, RSC Adv., 2016, 6, 96762
    DOI: 10.1039/C6RA23364C

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