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Issue 107, 2016, Issue in Progress
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Thermodynamic and conformational changes of protein toward interaction with nanoparticles: a spectroscopic overview

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Abstract

Nanoparticles (NPs) in different forms have been widely used in medicine and pharmaceutics for diagnosis and drug delivery. So, they are in intimate contact with bio-macromolecules like proteins which are vital and functional elements of cells and organisms. Thus, in vitro studies of the possible interaction between proteins and NPs are necessary from both application and toxicity points of view. In this article, binding characteristics and protein conformational change through interaction with various NPs have been reviewed. In recent years, a wide variety of biophysical techniques have been exploited to elucidate mechanistic aspects of NP–protein interactions. This study has focused on the information acquired from prevalent techniques including fluorescence quenching, synchronous fluorescence spectroscopy, circular dichroism (CD), and surface-enhanced Raman scattering (SERS).

Graphical abstract: Thermodynamic and conformational changes of protein toward interaction with nanoparticles: a spectroscopic overview

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Publication details

The article was received on 25 Jun 2016, accepted on 27 Oct 2016 and first published on 07 Nov 2016


Article type: Review Article
DOI: 10.1039/C6RA16422F
RSC Adv., 2016,6, 105903-105919

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    Thermodynamic and conformational changes of protein toward interaction with nanoparticles: a spectroscopic overview

    H. A. Zeinabad, E. Kachooei, A. A. Saboury, I. Kostova, F. Attar, M. Vaezzadeh and M. Falahati, RSC Adv., 2016, 6, 105903
    DOI: 10.1039/C6RA16422F

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