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Issue 14, 2016
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Smart stimuli-responsive fluorescent vesicular sensor based on inclusion complexation of cyclodextrins with Tyloxapol

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Abstract

Novel fluorescent vesicles based on inclusion complexes of β-cyclodextrins (β-CD) with Tyloxapol were constructed. For comparison, α-cyclodextrins (α-CD) were also selected to form inclusion complexes with Tyloxapol. The vesicles formed by β-CD/Tyloxapol were characterized thoroughly using various techniques including phase behavior observation, transmission electron microscopy (TEM), freeze fracture transmission electron microscopy (FF-TEM), field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM), 2D 1H–1H ROESY NMR, fluorescence spectra, Fourier transform infrared (FT-IR) spectroscopy, and X-ray diffraction (XRD). The results of TEM, SEM, FF-TEM, AFM indicated the formation of vesicles of β-CD/Tyloxapol; they presented aggregation-induced emission enhancement properties because the alkyl chain of Tyloxapol molecules enters the cavity of β-CD and forms inclusion complexes, while α-CD/Tyloxapol showed aggregation-induced quenching fluorescence emission properties owing to the interaction between PEO chain of Tyloxapol molecules and α-CD. Moreover, the vesicles of β-CD/Tyloxapol were responsive to external stimuli and their fluorescent intensities were changed by various environmental conditions such as urea, phenylalanine, α-amylase and NaOH. These properties made our vesicle a promising candidate as novel, smart, stimuli-responsive, fluorescent vesicular sensors.

Graphical abstract: Smart stimuli-responsive fluorescent vesicular sensor based on inclusion complexation of cyclodextrins with Tyloxapol

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Supplementary files

Article information


Submitted
11 Dec 2015
Accepted
14 Jan 2016
First published
18 Jan 2016

RSC Adv., 2016,6, 11683-11690
Article type
Paper

Smart stimuli-responsive fluorescent vesicular sensor based on inclusion complexation of cyclodextrins with Tyloxapol

J. Shen, J. Pang, G. Xu, X. Xin, Y. Yang, X. Luan and S. Yuan, RSC Adv., 2016, 6, 11683
DOI: 10.1039/C5RA26464B

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