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Issue 7, 2016
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MRI-visible polymer based on poly(methyl methacrylate) for imaging applications

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Abstract

Macromolecular contrast agents are very attractive to afford efficient magnetic resonance imaging (MRI) visualization of implantable medical devices. In this work, we report on the grafting of a Gd-based DTPA contrast agent onto a poly(methyl methacrylate) derivative backbone by combining free radical polymerization and copper-catalyzed azide-alkyne cycloaddition (CuAAC). Using free radical polymerization, poly(methyl methacrylate-co-propargyl methacrylate) copolymers were prepared with a control of the ratio in propargyl methacrylate monomer units. The synthesis of a new azido mono-functionalized DTPA ligand was also reported and characterized by 1H NMR and mass spectroscopy. After complexation with gadolinium, this ligand has been grafted on the polymer backbone by click chemistry reaction. The obtained macromolecular contrast agent was then coated on a polypropylene mesh using the airbrushing technique and the mesh was assessed for MRI visualization at 7 teslas. The polymeric contrast agent was also tested for cytocompatibility and stability to assess its suitability for biomedical applications.

Graphical abstract: MRI-visible polymer based on poly(methyl methacrylate) for imaging applications

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Supplementary files

Article information


Submitted
10 Nov 2015
Accepted
03 Jan 2016
First published
07 Jan 2016

RSC Adv., 2016,6, 5754-5760
Article type
Paper
Author version available

MRI-visible polymer based on poly(methyl methacrylate) for imaging applications

M. Younis, V. Darcos, C. Paniagua, P. Ronjat, L. Lemaire, B. Nottelet, X. Garric, Y. Bakkour, J. H. El Nakat and J. Coudane, RSC Adv., 2016, 6, 5754
DOI: 10.1039/C5RA23646K

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