Rhodium/copper-cocatalyzed annulation of benzylamines with diazo compounds: access to fused isoquinolines

Abstract

Benzylamine has been applied as an arene source in C–H activation and coupling with different types of diazo compounds, leading to the synthesis of fused isoquinolines. This occurs via a mild synergistic rhodium- and copper-catalyzed process. Moreover, ecofriendly O₂ has been used as a terminal oxidant with high efficiency.