Jump to main content
Jump to site search

Issue 10, 2016
Previous Article Next Article

Catalytic asymmetric direct-type 1,4-addition reactions of simple esters

Author affiliations

Abstract

In the presence of catalytic amounts of potassium hexamethyldisilazide (KHMDS) and a chiral macrocyclic crown ether, asymmetric 1,4-addition reactions of simple esters with α,β-unsaturated amides proceeded to afford the desired 1,4-adducts in high yields with good stereoselectivities. Mechanistic investigations revealed that proper combination of substrates was a key for the efficient catalytic turnover.

Graphical abstract: Catalytic asymmetric direct-type 1,4-addition reactions of simple esters

Back to tab navigation

Supplementary files

Article information


Submitted
31 May 2016
Accepted
28 Jun 2016
First published
29 Jun 2016

Org. Chem. Front., 2016,3, 1241-1245
Article type
Research Article

Catalytic asymmetric direct-type 1,4-addition reactions of simple esters

I. Sato, H. Suzuki, Y. Yamashita and S. Kobayashi, Org. Chem. Front., 2016, 3, 1241
DOI: 10.1039/C6QO00242K

Social activity

Search articles by author

Spotlight

Advertisements