Issue 10, 2016
From the journal:

Organic Chemistry Frontiers

Highly enantioselective Pd-catalyzed indole allylic alkylation using binaphthyl-based phosphoramidite-thioether ligands†

Bin Feng,a   Xiao-Yu Pu,a   Zhi-Cheng Liu,a   Wen-Jing Xiaoab  and  Jia-Rong Chen*a  

* Corresponding authors

a Key Laboratory of Pesticide & Chemical Biology, Ministry of Education; College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China
E-mail: chenjiarong@mail.ccnu.edu.cn

b State Key Laboratory of Applied Organic Chemistry Lanzhou University, Lanzhou 730000, China

Abstract

A novel type of binaphthyl-based phosphoramidite-thioether ligand has been developed and successfully applied to Pd-catalysed asymmetric C-3 allylic alkylation of indoles, giving the desired products with up to 99% yield and 98% ee.

Graphical abstract: Highly enantioselective Pd-catalyzed indole allylic alkylation using binaphthyl-based phosphoramidite-thioether ligands

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Article information

DOI
https://doi.org/10.1039/C6QO00227G
Article type
Research Article
Submitted
27 May 2016
Accepted
27 Jun 2016
First published
28 Jun 2016

Org. Chem. Front., 2016,3, 1246-1249

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Highly enantioselective Pd-catalyzed indole allylic alkylation using binaphthyl-based phosphoramidite-thioether ligands

B. Feng, X. Pu, Z. Liu, W. Xiao and J. Chen, Org. Chem. Front., 2016, 3, 1246 DOI: 10.1039/C6QO00227G

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