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Issue 16, 2016
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Disk-like micelles with cylindrical pores from amphiphilic polypeptide block copolymers

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Abstract

An unprecedented two-dimensional (2D) disk-like micelle with cylindrical pores was achieved for the first time by self-assembly of the amphiphilic block copolypeptide poly(ethylene glycol)-block-poly(γ-benzyl-L-glutamate) (PEG-b-PBLG) in solution. The aggregate structures were fully characterized by TEM, SEM, 1H NMR, AFM and CD. The research results showed that the α-helical conformation of PBLG blocks plays a key role in the formation process of a disk-like morphology. By tuning the ratio between the hydrophilic block and hydrophobic block in PEG-b-PBLG copolymers, various aggregate structures including micelles, disk-like micelles, vesicles and large vesicles can be achieved. The research results are helpful to expand the self-assembly fields and can provide more nanostructural materials.

Graphical abstract: Disk-like micelles with cylindrical pores from amphiphilic polypeptide block copolymers

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Supplementary files

Article information


Submitted
28 Jan 2016
Accepted
15 Mar 2016
First published
16 Mar 2016

Polym. Chem., 2016,7, 2815-2820
Article type
Paper
Author version available

Disk-like micelles with cylindrical pores from amphiphilic polypeptide block copolymers

X. Lin, X. He, C. Hu, Y. Chen, Y. Mai and S. Lin, Polym. Chem., 2016, 7, 2815
DOI: 10.1039/C6PY00152A

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