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Issue 41, 2016
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Total synthesis of wewakazole B

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Wewakazole B is a novel cyclodecapeptide with highly potent cytotoxic activity isolated from a sample of M. producens collected from the Red Sea. It contains nine common and three modified amino acid residues. The first total synthesis of Wewakazole B was successfully achieved on a gram scale, unambiguously confirming its structure. Notable features include the careful choice of amino acid-protecting groups and the construction of three different substituted oxazoles present in this natural product.

Graphical abstract: Total synthesis of wewakazole B

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The article was received on 16 Aug 2016, accepted on 28 Sep 2016 and first published on 28 Sep 2016

Article type: Communication
DOI: 10.1039/C6OB01783E
Org. Biomol. Chem., 2016,14, 9712-9715

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    Total synthesis of wewakazole B

    B. Long, J. Zhang, X. Tang and Z. Wu, Org. Biomol. Chem., 2016, 14, 9712
    DOI: 10.1039/C6OB01783E

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