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Issue 41, 2016
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Metal-free one-pot α-carboxylation of primary alcohols

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An efficient metal-free procedure for the formal α-carboxylation of primary alcohols has been developed. The method involves a one-pot oxidation/Passerini/hydrolysis sequence and provides access to α-hydroxy acids bearing a broad range of functional groups. A minor modification to the reaction conditions extends the range of accessible products to α-hydroxy esters.

Graphical abstract: Metal-free one-pot α-carboxylation of primary alcohols

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Publication details

The article was received on 19 Aug 2016, accepted on 28 Sep 2016 and first published on 28 Sep 2016

Article type: Communication
DOI: 10.1039/C6OB01813K
Citation: Org. Biomol. Chem., 2016,14, 9716-9719

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    Metal-free one-pot α-carboxylation of primary alcohols

    G. van der Heijden, J. Kraakman, J. Biemolt, E. Ruijter and R. V. A. Orru, Org. Biomol. Chem., 2016, 14, 9716
    DOI: 10.1039/C6OB01813K

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