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Issue 12, 2016
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A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

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Abstract

A new reagent system consisting of a Lewis acid such as BF3·Et2O or Cu(OTf)2, the mild protic acid hexafluoroisopropanol and the reducing quenching agent triethylsilane was elaborated for O-, N- and S-detritylation of nucleoside, carbohydrate and amino acid derivatives. The method is compatible with acetyl, silyl, acetal and Fmoc groups.

Graphical abstract: A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

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Article information


Submitted
11 Jan 2016
Accepted
01 Feb 2016
First published
01 Feb 2016

Org. Biomol. Chem., 2016,14, 3190-3192
Article type
Communication

A three-component reagent system for rapid and mild removal of O-, N- and S-trityl protecting groups

M. Kicsák, M. Bege, I. Bereczki, M. Csávás, M. Herczeg, Z. Kupihár, L. Kovács, A. Borbás and P. Herczegh, Org. Biomol. Chem., 2016, 14, 3190
DOI: 10.1039/C6OB00067C

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