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Abstract | Cited by

The Michael reaction of substituted isorhodanines with α,β-unsaturated aldehydes in the presence of a catalytic amount of a chiral secondary amine is presented. This transformation proceeds in good to high yields furnishing the corresponding 4,5-disubstituted isorhodanine adducts in good to excellent enantioselectivities.

Graphical abstract: Enantioselective organocatalytic Michael addition of isorhodanines to α,β-unsaturated aldehydes

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